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KMID : 0388220110180040306
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Journal of the Korean Rheumatism Association
2011 Volume.18 No. 4 p.306 ~ p.310
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A Case of Steroid and Methotrexate-Resistant Eosinophilic Fasciitis Treated with Adalimumab
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Lee Sang-Soo
Kim Hyun-Ok
Na Jae-Boem
Lee Jong-Sil
Suh Young-Sun
Cheon Yun-Hong
Kang Min-Gyu
Kim Yu-Eun
Lee Sang-Il
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Abstract
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Eosinophilic fasciitis (EF) is a rare fibrosing disorder characterized by painful swelling and induration of the limbs and trunk, characteristic histology with sclerosis and lymphocytic inflammation affecting the fascia. The cause and pathogenesis of EF are still unknown and current therapies include glucocorticoids with or without use of immunosuppressive agents. Recently, there have been several case reports documenting the efficacy of a TNF alpha inhibitor in EF following a steroid-resistant disease course. However, there has been no report on the experience in treatment of EF with a TNF alpha inhibitor in Korea. Hence, we report a case of steroid and methotrexate-resistant EF which was successfully treated with adalimumab, along with a review of the relevant articles.
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KEYWORD
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Eosinophilic fasciitis, Glucocorticoid, TNF alpha inhibitor
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